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De-Stress the Heart
Introducing SAVM: Splanchnic Ablation for Volume Management
Treating a root cause of Heart Failure, rather than just the signs and symptoms. 
Using the Axon™ Ablation System, SAVM unilaterally ablates the Greater Splanchnic Nerve to calm sympathetic activity with the goal of normalizing volume balance, increasing cardiac functional capacity and improving symptoms for heart failure patients with preserved ejection fraction (HFpEF).
The Problem

Heart Failure patients have a 50% 5-year survival rate

Heart Failure patients with preserved ejection fraction (HFpEF) account for ~50% of all patients1

There are limited
therapies for treating
patients with HFpEF

A hallmark of heart failure progression is an overactive sympathetic nervous system (SNS). The SAVM procedure aims to calm sympathetic nerve activity and address a root cause of heart failure.

The SAVM Procedure

During the implant-free procedure, the Axon Ablation Catheter is inserted into the femoral vein, navigated through the venous system to a target vessel near the right greater splanchnic nerve.

Once there, the vessel is treated with targeted ablation therapy to block nerve signals, diminishing sympathetic activity and normalizing volume balance in the body. 

The outpatient procedure can typically be performed in under an hour.

Minimally invasive, implant-free procedure Minimally invasive, implant-free procedure
Designed to reverse heart congestion Designed to reverse heart congestion
Safe, innovative solution Safe, innovative solution
Rebalance-HF Responder Cohort
6-month results, presented at HFSA 2023 in Cleveland, OH.
Reduced peak-PCWP
Improved Quality of Life
Increase in 6-min. walk

1 Fudim M et al. J Am Heart Assoc. 2017 Aug 17;6(8)

The Axon Ablation System is an investigational device and is not currently approved for clinical use in any geography.

CAUTION – Investigational Device. Limited by Federal (or United States) law to Investigational Use. identifier:  NCT04592445

Patent information

© Axon Therapies Inc. All rights reserved. Axon™ is a trademark of Axon Therapies, Inc.