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Rebalancing Heart Failure
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Introducing SAVM: Splanchnic Ablation for Volume Management
Treating a root cause of Heart Failure, rather than just the signs and symptoms. 
Using the Axon™ Ablation System, SAVM unilaterally ablates the Greater Splanchnic Nerve to reduce sympathetic activity with the goal of restoring volume balance, increasing cardiac functional capacity and improving symptoms for heart failure patients with preserved ejection fraction (HFpEF).
The Problem
Heart Failure patients have a 50% 5-year survival rate
Heart Failure patients with preserved ejection fraction (HFpEF) account for ~50% of all patients1
There are limited
therapies for treating
patients with HFpEF

A hallmark of heart failure progression is an overactive sympathetic nervous system (SNS). The SAVM procedure aims to reduce sympathetic nerve activity and address a root cause of heart failure.

The SAVM Procedure

During the implant-free procedure, the Axon Ablation Catheter is inserted into the femoral vein, navigated through the venous system to a target vessel near the right greater splanchnic nerve.

Once there, the vessel is treated with targeted ablation therapy to block nerve signals, reducing sympathetic activity and restoring volume balance in the body. 

The outpatient procedure can typically be performed in under an hour.

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Minimally invasive, implant-free procedure Minimally invasive, implant-free procedure
Designed to reverse heart congestion Designed to reverse heart congestion
Safe, innovative solution Safe, innovative solution
Clinical Experience
SAVM First-in-Human results with 11 HFpEF patients, followed for 12 months.2
Improved
Quality of Life
+37
in KCCQ
Reduced
NT-proBNP
-55
%
Increase in
6-min. walk
+67
meters
No Device-Related
Adverse Events
0

1 Fudim M et al. J Am Heart Assoc. 2017 Aug 17;6(8)

2 S. Shah. Presented at 2021 Heart Failure Soicety of America (HFSA) Annual Meeting, Denver, CO.

The Axon Ablation System is an investigational device and is not currently approved for clinical use in any geography.

CAUTION – Investigational Device. Limited by Federal (or United States) law to Investigational Use.

 ClinicalTrials.gov identifier:  NCT04592445

©2022 Axon Therapies Inc. All rights reserved. Axon is a trademark of Axon Therapies, Inc.
Patent information